Pijem Controloc već neko vreme i od njega imam blago povišen pritisak i glavobolju. Kolike su šanse da iste neželjene efekte imam i od Nexiuma? Vredili da se javljam internisti na kontrolu?

CONTROLOC®
Each tablet contains 45,1 mg pantoprazole sodium sesquihydrate equivalent to 40 mg pantoprazole.

PHARMACOLOGICAL CLASSIFICATION
A.11.4.3 Medicines acting on the gastro-intestinal tract.

PHARMACOLOGICAL ACTION
Site and mechanism of action
Pantoprazole is a proton pump inhibitor, i.e., it inhibits specifically and dose proportionally H+,K+ -ATPase, the enzyme which is responsible for gastric acid secretion in the parietal cells of the stomach.
Pantoprazole is a substituted benzimidazole which accumulates in the acidic compartment of the parietal cells after absorption. In the parietal cell it is protonated and chemically re-arranged to the active inhibitor, a cyclic sulphenamide, which binds to the H+,K+-ATPase, thus inhibiting the proton pump and causing suppression of stimulated and basal gastric acid secretion after single and multiple intravenous and oral pantoprazole dosing. Because pantoprazole acts distal to the receptor level, it can influence gastric acid secretion irrespective of the nature of the stimulus.
Pantoprazole exerts its full effect in a strongly acidic environment (pH<3) and remains mostly inactive at higher pH values, which explains its selectivity for the acid secreting parietal cells of the stomach. Therefore, the complete pharmacological and therapeutic effect for pantoprazole can only be achieved in the acid-secreting parietal cells. By means of a feedback mechanism this effect is diminished at the same rate as acid secretion is inhibited.
CONTRA-INDICATIONS
Hypersensitivity to pantoprazole.
Safety in pregnancy and during lactation has not been established.
Safety and efficacy in children have not been established.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS
Side-effects
Headaches and gastro-intestinal complaints such as upper abdominal pain, diarrhoea, constipation or flatulence have been reported. With continued treatment complaints usually diminish. There have been reports of allergic reactions such as skin rash, pruritus and in isolated cases also urticaria, angioedema or anaphylactic shock.
There have been less frequent reports of nausea, dizziness or disturbances in vision (blurred vision).
Peripheral edema, depression, fever or myalgia have been reported in individual cases.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
There are no known symptoms of overdosage in man. No specific therapeutic recommendation can be made in cases of overdosage.

[b]Sastav: pantoprazole a Nexium: esomeprazole magnesium
Nema neke bitne razlike u delovanju niti u nezeljenim dejstvima.
Ne vidim razlog zasto bi vam ovi lekovi stvarali hipertenziju, bice pre da je kod vas hipertenzija poseban entitet i treba da je lecite.

Pritisak sam samo jednom merio i imao povišen, a glavobolju imam svakodnevno. To i piše da je najčešće neželjeno dejstvo.

Uvek imam 120/80 a sada sam imao 129/94 ... ima li šanse da je to zapravo uzrok glavobolja?

OK.

A već neko vreme (oko 2 meseca) imam temperaturu 37.2 .. i to uvek tačno tu temperaturu (merio sam sa više različitih toplomera bar 20 puta do sada) ... temperatura povremeno spadne i oblije me hladan znoj u tom trenutku .. Da li to može da bude od pristiska? Ja sam to do sada prepisivao stomaku, jer su mi ispucale usne i tople su pa sam mislio da je od toga...

Inače, bris grla i nosa su OK, kao i analiza stolice na bakterije, gljivice i parazite ...

A meni su rekli da temperatura može da bude od želudca

A da ... sorry, nisam obratio pažnju.



Ja sam načuo da kod jakih upala želudačne sluznice izazvane lekovima može da dođe do temperature preko 37. Hvala na odgovoru, videću šta mi sutra kaže infektolog

Draganvma, hvala vam na pređašnjim postovima.

Bio sam kod infektologa-gastroenterologa i dao mi je uput za bolničko ležanje kako bi mi uradili sve testove koje moj opšti lekar nije predlagao. Javiću se u ovoj temi kada izađem iz bolnice.

Gastroskopija želudca mi je pokazala da je želudac samo iziritiran, i da nije oštećen.

Po izlasku iz bolnice došlo je vreme da smanjim terapiju (tako mi je lekar prepisao) na 20mg ali od tada imam gasove u želudcu koji izbijaju na usta kao neko tiho podrigivanje. Prepisan mi je Controloc u trajanju od mesec i po dana a posle 3 nedelje da pređem sa 40mg na 20mg.

Ponovo sam otišao kod infektologa-gastroenterologa i on mi je posle pipanja stomaka promenio terapiju u Nexium 40(mg). Pregled je trajao svega par minuta pa nisam stigao da ga pitam od čega je ovo podrigivanje?


Inače, pre uvođenja Controloca stomak mi je bio lako meteorističan. Da li je moguće da je smanjenje terapije uticalo na stvaranje ovih gasova i da li će mi Nexium pomoći?